\name{ASAT}
\alias{ASAT}
\docType{data}
\title{ Toxicological Study on Female Wistar Rats }
\description{
  ASAT-Values for a new compound and a control group of 34 female Wistar
rats.
}
\usage{data(ASAT)}
\format{
  A data frame with 34 observations on the following 2 variables.
  \describe{
    \item{asat}{the ASAT-values (a liver enzyme)}
    \item{group}{a factor with levels \code{Compound} and \code{Control}.}
  }
}
\details{
  The aim of this toxicological study is the proof of safety for the new
compound. The data are originally given in Hothorn (1992) and reproduced in
Hauschke et al. (1999).
}
\source{

  Ludwig A. Hothorn (1992), Biometrische Analyse toxikologischer Untersuchungen.
  In: J. Adams (ed.): \emph{Statistisches Know how in der medizinischen 
  Forschung.} Ullstein-Mosby, Berlin, 475--590.

}
\references{

  Dieter Hauschke, Meinhard Kieser & Ludwig A. Hothorn (1999), 
  Proof of safety in
  toxicology based on the ratio of two means for normally distributed data.
  \emph{Biometrical Journal}, \bold{41}(3), 295--304.

  Rafael Pfl\"uger & Torsten Hothorn (2002),
  Assessing Equivalence Tests with Respect to their Expected
  $p$-Value. \emph{Biometrical Journal}, \bold{44}(8), 1002--1027.

}
\examples{

data(ASAT)
# does not really look symmetric

plot(asat ~ group, data=ASAT)

# proof-of-safety based on ration of medians
pos <- wilcox.exact(I(log(asat)) ~ group, data = ASAT, alternative = "less", 
             conf.int=TRUE)

# one-sided confidence set. Safety cannot be concluded since the effect of
# the compound exceeds 20\% of the control median
exp(pos$conf.int)
}
\keyword{datasets}
